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IMDA-radical cyclization approach to (+)-himbacine

被引：39
作者：
Wong, LSM
Sherburn, MS
机构：
[1] Australian Natl Univ, Res Sch Chem, Canberra, ACT 0200, Australia
[2] Univ Sydney, Sch Chem, Sydney, NSW 2006, Australia
来源：
ORGANIC LETTERS | 2003年 / 5卷 / 20期
关键词：
D O I：
10.1021/ol0353058
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A formal total synthesis of the selective muscarinic receptor antagonist himbacine is presented. Key C-C bond-forming steps include an intramolecular Diels-Alder reaction, Stille coupling reactions, and a 6-exo-trig acyl radical cyclization to a conjugated enyne. An unexpected secondary alcohol to chloride conversion is witnessed during attempted thionocarbonate formation.
引用
收藏
页码：3603 / 3606
页数：4
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