Hydroxyapatite-collagen composites. Part I: can the decrease of the interactions between the two components be a physicochemical component of osteoporosis in aged bone?

被引：7

作者：

Barbani, Niccoletta ^{[2
]}

Rosellini, Elisabetta ^{[2
]}

Cristallini, Caterina ^{[1
]}

Guerra, Giulio D. ^{[1
]}

Krajewski, Adriano ^{[3
]}

Mazzocchi, Mauro ^{[3
]}

机构：

[1] CNR, UOS Pisa, IMCB, I-56122 Pisa, Italy

[2] Univ Pisa, Dipartimento Ingn Chim Chim Ind & Sci Mat, I-56122 Pisa, Italy

[3] CNR, ISTEC, I-48018 Faenza, RA, Italy

来源：

JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE | 2011年 / 22卷 / 03期

关键词：

POSTMENOPAUSAL WOMEN; FRACTURES; RISK; BISPHOSPHONATES; PREVENTION; JAWS;

D O I：

10.1007/s10856-011-4238-2

中图分类号：

R318 [生物医学工程];

学科分类号：

100103 [病原生物学];

摘要：

The interactions of Type I acid soluble collagen (Col) with both carbonate-free hydroxyapatite (HA(1100)) and carbonate-rich one (CHA) were investigated. The aim was to ascertain whether the increase of bone CO3 (2-) with ageing could relate to the disease known as osteoporosis. HA(1100)-Col and CHA-Col composites with various ratios were prepared and examined. Scanning electron microscopy and differential scanning calorimetry showed a stronger adhesion of the Col matrix to the granules of HA(1100) than to those of CHA. FT-IR spectroscopy showed that with HA(1100) both multiple hydrogen bonds of Col peptide -NH groups with HA PO4 (3-), and electrochemical interactions between Col peptide -C=O groups and HA Ca2+ were present. In the presence of CO3 (2-), the interactions between -NH and phosphate were diminished, and Ca2+ interacted more strongly with CO3 (2-) than with peptide -C=O, so causing a separation between the two components of the bone extra-cellular matrix. The results obtained strengthen the hypothesis that the substitution of PO4 (3-) ions by CO3 (2-) ions in the HA lattice might be a significant component of osteoporosis, although further investigation is needed.

引用

页码：637 / 646

页数：10

共 32 条

[1]

BERTONI F, 2006, P 20 EUR C BIOM NANT

[2]

Acid-base imbalance and the skeleton [J].