Mineral changes in osteoporosis - A review

被引:116
作者
Faibish, Dan
Ott, Susan M.
Boskey, Adele L.
机构
[1] Hosp Special Surg, Musculoskeletal Integr Program, New York, NY 10021 USA
[2] Univ Washington, Dept Med, Seattle, WA USA
关键词
D O I
10.1097/01.blo.0000200241.14684.4e
中图分类号
R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学(修复外科学)];
学科分类号
摘要
Bone mineral composition, crystallinity, and bone mineral content of osteoporotic patients are different from those of normal subjects. We review the evidence that these mineralization parameters contribute to the strength (fracture resistance) of bone and the methods that have been used to examine them. A specific example is provided from analysis of biopsies from the Multiple Outcomes in Raloxifene Evaluation trial. For the analyses, randomly selected biopsies from placebo, low-dose, and high-dose groups (n = 5 per group) obtained at time zero and 2 years after treatment were examined by infrared imaging spectroscopy. In all cases, comparable increases in mineral content were found, but there were no significant variations in mineral crystallinity.
引用
收藏
页码:28 / 38
页数:11
相关论文
共 131 条
[1]   Age-related changes in physicochemical properties of mineral crystals are related to impaired mechanical function of cortical bone [J].
Akkus, O ;
Adar, F ;
Schaffler, MB .
BONE, 2004, 34 (03) :443-453
[2]   Optimal methods for processing mineralized tissues for Fourier transform infrared microspectroscopy [J].
Aparicio, S ;
Doty, SB ;
Camacho, NP ;
Paschalis, EP ;
Spevak, L ;
Mendelsohn, R ;
Boskey, AL .
CALCIFIED TISSUE INTERNATIONAL, 2002, 70 (05) :422-429
[3]   Overexpression of IGF-binding protein 5 alters mineral and matrix properties in mouse femora: An infrared imaging study [J].
Atti, E ;
Boskey, AL ;
Canalis, E .
CALCIFIED TISSUE INTERNATIONAL, 2005, 76 (03) :187-193
[4]   Effect of estrogen deficiency on cancellous and cortical bone structure and strength of the femoral neck in rats [J].
Bagi, CM ;
Ammann, P ;
Rizzoli, R ;
Miller, SC .
CALCIFIED TISSUE INTERNATIONAL, 1997, 61 (04) :336-344
[5]   BIOCHEMICAL-CHANGES IN THE COLLAGEN OF HUMAN OSTEOPOROTIC BONE-MATRIX [J].
BAILEY, AJ ;
WOTTON, SF ;
SIMS, TJ ;
THOMPSON, PW .
CONNECTIVE TISSUE RESEARCH, 1993, 29 (02) :119-132
[6]   BIOPHYSICAL STUDY OF BONE-MINERAL IN BIOPSIES OF OSTEOPOROTIC PATIENTS BEFORE AND AFTER LONG-TERM TREATMENT WITH FLUORIDE [J].
BAUD, CA ;
VERY, JM ;
COURVOISIER, B .
BONE, 1988, 9 (06) :361-365
[7]   Spectroscopically determined collagen Pyr/deH-DHLNL cross-link ratio and crystallinity indices differ markedly in recombinant congenic mice with divergent calculated bone tissue strength [J].
Blank, RD ;
Baldini, TH ;
Kaufman, M ;
Bailey, S ;
Gupta, R ;
Yershov, Y ;
Boskey, AL ;
Coppersmith, SN ;
Demant, P ;
Paschalis, EP .
CONNECTIVE TISSUE RESEARCH, 2003, 44 (3-4) :134-142
[8]   Determining mineral content variations in bone using backscattered electron imaging [J].
Bloebaum, RD ;
Skedros, JG ;
Vajda, EG ;
Bachus, KN ;
Constantz, BR .
BONE, 1997, 20 (05) :485-490
[9]   Characterization of the trabecular rat bone mineral: Effect of ovariectomy and bisphosphonate treatment [J].
Bohic, S ;
Rey, C ;
Legrand, A ;
Sfihi, H ;
Rohanizadeh, R ;
Martel, C ;
Barbier, A ;
Daculsi, G .
BONE, 2000, 26 (04) :341-348
[10]   The mineralization of bone tissue: a forgotten dimension in osteoporosis research [J].
Boivin, G ;
Meunier, PJ .
OSTEOPOROSIS INTERNATIONAL, 2003, 14 (Suppl 3) :S19-S24