Slow releasing of ara-C from poly(2-hydroxyethyl methacrylate) and poly(2-hydroxyethyl methacrylate-co-N-vinyl-2-pyrrolidone) hydrogels implanted subcutaneously in the back of rats

被引:21
作者
Blanco, MD [1 ]
Trigo, RM [1 ]
Teijón, C [1 ]
Gómez, C [1 ]
Teijón, JM [1 ]
机构
[1] Univ Complutense Madrid, Fac Med, Dept Bioquim & Biol Mol, E-28040 Madrid, Spain
关键词
implant; ara-C; hydrogel; controlled release;
D O I
10.1016/S0142-9612(97)00247-0
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
The release of cytarabine (ara-C) from poly(2-hydroxyethyl methacrylate) and poly(2-hydroxyethyl methacrylate-co-N-vinyl-2-pyrrolidone) hydrogels cross-linked with different amounts of ethyleneglycol dimethacrylate (EGDMA) 'in vivo' has been studied. Two ara-C loaded hydrogel discs, each with 25 mg of the drug, were subcutaneously implanted in the back of male Wistar rats. Total ara-C dose was 230 mg kg(-1). Ara-C and ara-U plasmatic concentration were determined by HPLC. Periods of constant drug concentration are observed from all gels. Ara-C concentrations in the steady-slate are between 19.0 +/- 2.0 and 2.2 +/- 0.8 mu mol l(-1). The release lime of ara-C was between 3 days from pHEMA 0.5% and 16 days from H80/VP20/E15 gels. These results are very different of that obtained when ara-C is administered by intraperitoneal injection, in this case peaks of maximum concentration (between 24 +/- 1 and 3.9 +/- 0.4 mu g ml(-1)) 30 min after the injection are originated, and no drug is detected 4 h after the injection. (C) 1998 Published by Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:861 / 869
页数:9
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