A multifunctional nanoassembly of mesogen-bearing amphiphiles and porphyrins for the simultaneous photodelivery of nitric oxide and singlet oxygen

被引:28
作者
Caruso, Elisa B. [1 ]
Cicciarella, Enzo [1 ]
Sortino, Salvatore [1 ]
机构
[1] Univ Catania, Dipartimento Sci Chim, I-95125 Catania, Italy
关键词
D O I
10.1039/b713372c
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
We report a molecular nanoassembly able to supply simultaneously, in the same region of space and under the exclusive control of visible light, nitric oxide and singlet oxygen, two species playing a key role in the therapy of cancer; the considerable fluorescence of this nanoaggregate and its reduced size (ca. 40 nm) represent additional advantages that make this photoactive vehicle an appealing candidate to be tested in biological systems.
引用
收藏
页码:5028 / 5030
页数:3
相关论文
共 21 条
[1]   Photodelivery of nitric oxide from water-soluble platinum nanoparticles [J].
Caruso, Elisa B. ;
Petralia, Salvatore ;
Conoci, Sabrina ;
Giuffrida, Salvatore ;
Sortino, Salvatore .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2007, 129 (03) :480-481
[2]   NO NEWS IS GOOD-NEWS [J].
CULOTTA, E ;
KOSHLAND, DE .
SCIENCE, 1992, 258 (5090) :1862-1865
[3]   EFFECTS OF INTRODUCTION OF MESOGENIC UNITS IN AMMONIUM AMPHIPHILES ON THE AGGREGATION BEHAVIOR IN WATER [J].
EVERAARS, MD ;
MARCELIS, ATM ;
KUIJPERS, AJ ;
LAVERDURE, E ;
KORONOVA, J ;
KOUDIJS, A ;
SUDHOLTER, EJR .
LANGMUIR, 1995, 11 (10) :3705-3711
[4]  
Furchgott RF, 1999, ANGEW CHEM INT EDIT, V38, P1870, DOI 10.1002/(SICI)1521-3773(19990712)38:13/14<1870::AID-ANIE1870>3.0.CO
[5]  
2-8
[6]   Targeting nitric oxide to cancer cells:: Cytotoxicity studies of glyco-S-nitrosothiols [J].
Hou, YC ;
Wang, JQ ;
Andreana, PR ;
Cantauria, G ;
Tarasia, S ;
Sharp, L ;
Braunschweiger, PG ;
Wang, PG .
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1999, 9 (15) :2255-2258
[7]  
Ignarro LJ, 2000, NITRIC OXIDE BIOL PA, P41
[8]  
Jia QA, 2002, EXPERT OPIN THER PAT, V12, P819
[9]   Novel approaches towards a detailed control of the mechanism and efficiency of photosensitized processes in vivo [J].
Jori, G ;
Schindl, L ;
Schindl, A ;
Polo, L .
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY, 1996, 102 (01) :101-107
[10]   J- and H-aggregates of porphyrin-surfactant complexes: Time-resolved fluorescence and other spectroscopic studies [J].
Maiti, NC ;
Mazumdar, S ;
Periasamy, N .
JOURNAL OF PHYSICAL CHEMISTRY B, 1998, 102 (09) :1528-1538