Combinatorial chemistry. Use of an intramolecular ruthenium catalyzed olefin/alkyne metathesis reaction in tandem with a Diels-Alder cycloaddition reaction to construct functionalized hexahydroisoindoles.

被引：50

作者：

Heerding, DA ^{[1
]}

Takata, DT ^{[1
]}

Kwon, C ^{[1
]}

Huffman, WF ^{[1
]}

Samanen, J ^{[1
]}

机构：

[1] SmithKline Beecham Pharmaceut, Dept Med Chem, Collegeville, PA 19426 USA

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 38期

关键词：

combinatorial chemistry; metathesis; Diels-Alder reactions;

D O I：

10.1016/S0040-4039(98)01473-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We show here the first example of a ruthenium catalyzed ene-yne metathesis reaction in tandem with a Diels-Alder cycloaddition reaction to efficiently form highly substituted hexahydroisoindole ring systems on Wang resin. This approach was used to prepare a 4200 membered combinatorial library. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：6815 / 6818

页数：4

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