Designed epothilones: Combinatorial synthesis, tubulin assembly properties, and cytotoxic action against taxol-resistant tumor cells

被引：174

作者：

Nicolaou, KC

Vourloumis, D

Li, TH

Pastor, J

Winssinger, N

He, Y

Ninkovic, S

Sarabia, F

Vallberg, H

Roschangar, F

King, NP

Finlay, MRV

Giannakakou, P

VerdierPinard, P

Hamel, E

机构：

[1] Scripps Res Inst, SKAGGS INST CHEM BIOL, LA JOLLA, CA 92037 USA

[2] UNIV CALIF SAN DIEGO, DEPT CHEM & BIOCHEM, LA JOLLA, CA 92093 USA

[3] NCI, MED BRANCH, DIV CLIN SCI, NIH, BETHESDA, MD 20892 USA

[4] NCI, LAB DRUG DISCOVERY RES & DEV, DEV THERAPEUT PROGRA, DIV CANC TREATMENT DIAG & CTR, FREDERICK, MD 21702 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 1997年 / 36卷 / 19期

关键词：

antitumor agents; combinatorial chemistry; epothilones; microreactors; structure-activity relationships;

D O I：

10.1002/anie.199720971

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

[No abstract available]

引用

页码：2097 / 2103

页数：7

共 59 条

[1]

[Anonymous], [No title captured], Patent No. [DE 4138042, 4138042]

[2] Stereoselective syntheses and evaluation of compounds in the 8-desmethylepothilone A series: Some surprising observations regarding their chemical and biological properties [J].

Balog, A ;

Bertinato, P ;

Su, DS ;

Meng, DF ;

Sorensen, E ;

Danishefsky, SJ ;

Zheng, YH ;

Chou, TC ;

He, LE ;

Horwitz, SB .

TETRAHEDRON LETTERS, 1997, 38 (26) :4529-4532

[3] Total synthesis of (-)-epothilone A [J].

Balog, A ;

Meng, DF ;

Kamenecka, T ;

Bertinato, P ;

Su, DS ;

Sorensen, EJ ;

Danishefsky, S .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH, 1996, 35 (23-24) :2801-2803

[4]

Balog A., 1996, Angew. Chem, V108, P2976

[5]

BEHRENS BC, 1987, CANCER RES, V47, P414

[6] Studies toward a synthesis of epothilone A: Stereocontrolled assembly of the acyl region and models for macrocyclization [J].

Bertinato, P ;

Sorensen, EJ ;

Meng, DF ;

Danishefsky, SJ .

JOURNAL OF ORGANIC CHEMISTRY, 1996, 61 (23) :8000-8001

[7]

BOLLAG DM, 1995, CANCER RES, V55, P2325

[8] THE FIRST SYNTHESIS OF THE ABCD RING-SYSTEM OF MANZAMINE-A - CONSTRUCTION OF THE MACROCYCLIC RING-D [J].

BORER, BC ;

DEERENBERG, S ;

BIERAUGEL, H ;

PANDIT, UK .

TETRAHEDRON LETTERS, 1994, 35 (19) :3191-3194

[9] SUPRAMOLECULAR DESIGN BY COVALENT CAPTURE - DESIGN OF A PEPTIDE CYLINDER VIA HYDROGEN-BOND-PROMOTED INTERMOLECULAR OLEFIN METATHESIS [J].

CLARK, TD ;

GHADIRI, MR .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1995, 117 (49) :12364-12365

[10] Synthesis of the C1-C9 segment of epothilons [J].

Claus, E ;

Pahl, A ;

Jones, PG ;

Meyer, HM ;

Kalesse, M .

TETRAHEDRON LETTERS, 1997, 38 (08) :1359-1362

← 1 2 3 4 5 6 →