Impact of genetic analysis on Parkinson's disease research

被引：9

作者：

Hardy, J

机构：

[1] NIA, Neurogenet Lab, NIH, Bethesda, MD 20892 USA

[2] UCL, Sch Med, Reta Lila Weston Inst Neurol Studies, London W1N 8AA, England

来源：

MOVEMENT DISORDERS | 2003年 / 18卷

关键词：

synuclein; parkin; Parkinson's disease; genetics; ubiquitin hydrolase; proteasone;

D O I：

10.1002/mds.10569

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Genetic analysis is changing our view of Parkinson's disease: not only is it challenging the long-cherished views about the diagnosis of the disease, it is also starting to suggest a biochemical pathway to disease pathogenesis. These developments are reviewed in the context of three known (synuclein, parkin, and DJ-1) and one suspected (ubiquitin hydrolase) genes for the disease. (C) 2003 Movement Disorder Society.

引用

页码：S96 / S98

页数：3

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