Impact of genetic analysis on Parkinson's disease research

被引：9

作者：

Hardy, J

机构：

[1] NIA, Neurogenet Lab, NIH, Bethesda, MD 20892 USA

[2] UCL, Sch Med, Reta Lila Weston Inst Neurol Studies, London W1N 8AA, England

来源：

MOVEMENT DISORDERS | 2003年 / 18卷

关键词：

synuclein; parkin; Parkinson's disease; genetics; ubiquitin hydrolase; proteasone;

D O I：

10.1002/mds.10569

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Genetic analysis is changing our view of Parkinson's disease: not only is it challenging the long-cherished views about the diagnosis of the disease, it is also starting to suggest a biochemical pathway to disease pathogenesis. These developments are reviewed in the context of three known (synuclein, parkin, and DJ-1) and one suspected (ubiquitin hydrolase) genes for the disease. (C) 2003 Movement Disorder Society.

引用

页码：S96 / S98

页数：3

共 17 条

[11] Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism [J].

Kitada, T ;

Asakawa, S ;

Hattori, N ;

Matsumine, H ;

Yamamura, Y ;

Minoshima, S ;

Yokochi, M ;

Mizuno, Y ;

Shimizu, N .

NATURE, 1998, 392 (6676) :605-608

[12] The ubiquitin pathway in Parkinson's disease [J].

Leroy, E ;

Boyer, R ;

Auburger, G ;

Leube, B ;

Ulm, G ;

Mezey, E ;

Harta, G ;

Brownstein, MJ ;

Jonnalagada, S ;

Chernova, T ;

Dehejia, A ;

Lavedan, C ;

Gasser, T ;

Steinbach, PJ ;

Wilkinson, KD ;

Polymeropoulos, MH .

NATURE, 1998, 395 (6701) :451-452

[13] Case-control study of the ubiquitin carboxy-terminal hydrolase L1 gene in Parkinson's disease [J].

Maraganore, DM ;

Farrer, MJ ;

Hardy, JA ;

Lincoln, SJ ;

McDonnell, SK ;

Rocca, WA .

NEUROLOGY, 1999, 53 (08) :1858-1860

[14] Hereditary form of parkinsonism-dementia [J].

Muenter, MD ;

Forno, LS ;

Hornykiewicz, O ;

Kish, SJ ;

Maraganore, DM ;

Caselli, RJ ;

Okazaki, H ;

Howard, FM ;

Snow, BJ ;

Calne, DB .

ANNALS OF NEUROLOGY, 1998, 43 (06) :768-781

[15] Parkin protects against the toxicity associated with mutant α-synuclein:: Proteasome dysfunction selectively affects catecholaminergic neurons [J].

Petrucelli, L ;

O'Farrell, C ;

Lockhart, PJ ;

Baptista, M ;

Kehoe, K ;

Vink, L ;

Choi, P ;

Wolozin, B ;

Farrer, M ;

Hardy, J ;

Cookson, MR .

NEURON, 2002, 36 (06) :1007-1019

[16] Mutation in the alpha-synuclein gene identified in families with Parkinson's disease [J].

Polymeropoulos, MH ;

Lavedan, C ;

Leroy, E ;

Ide, SE ;

Dehejia, A ;

Dutra, A ;

Pike, B ;

Root, H ;

Rubenstein, J ;

Boyer, R ;

Stenroos, ES ;

Chandrasekharappa, S ;

Athanassiadou, A ;

Papapetropoulos, T ;

Johnson, WG ;

Lazzarini, AM ;

Duvoisin, RC ;

DiIorio, G ;

Golbe, LI ;

Nussbaum, RL .

SCIENCE, 1997, 276 (5321) :2045-2047

[17] Parkinson's genetics: Molecular insights for the new millennium [J].

Skipper, L ;

Farrer, M .

NEUROTOXICOLOGY, 2002, 23 (4-5) :503-514

← 1 2 →