Free radicals and diseases in premature infants

被引：66

作者：

O'Donovan, DJ ^{[1
]}

Fernandes, CJ ^{[1
]}

机构：

[1] Baylor Coll Med, Sect Neonatol, Dept Pediat, Houston, TX 77030 USA

来源：

ANTIOXIDANTS & REDOX SIGNALING | 2004年 / 6卷 / 01期

关键词：

D O I：

10.1089/152308604771978471

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Free radicals have been implicated in the pathogenesis of a wide spectrum of human diseases. Premature infants are probably developmentally unprepared for extrauterine life in an oxygen-rich environment and exhibit a unique sensitivity to oxidant injury. Diseases associated with premature infants, including bronchopulmonary dysplasia, periventricular leukomalacia, intraventricular hemorrhage, retinopathy of prematurity, and necrotizing enterocolitis, have been linked to free radical-mediated cell and tissue injury. With the advent of therapies designed to combat the injurious effects of free radicals, the role of these highly reactive chemical molecules in the pathogenesis of neonatal diseases needs to be fully determined.

引用

页码：169 / 176

页数：8

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