Practical synthesis of taxol side chain

被引：23

作者：

Ha, HJ ^{[1
]}

Park, GS

Ahn, YG

Lee, GS

机构：

[1] Hankuk Univ Foreign Studies, Dept Chem, Kyunggi Do 449791, South Korea

[2] Hanmi Pharmaceut Co Ltd, Cent Res Inst, Kyunggi Do 463400, South Korea

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1998年 / 8卷 / 13期

关键词：

taxol side chain; synthesis; imine; stereochemistry;

D O I：

10.1016/S0960-894X(98)00271-6

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Practical large scale synthesis of N-benzoyl-(2R,3S)-phenylisoserine methyl ester of the Taxol side chain has been attained from the coupling of chiral imine of N-[(S)-methylbenzyl]benzaldimine with (Z)-alpha-methoxy trimethylsilyl ketene acetal followed by the sequential reactions of lactamization, demethylation, methanolysis and N-benzoylation. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：1619 / 1622

页数：4

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