Epigenetic reprogramming of host genes in viral and microbial pathogenesis

被引：176

作者：

Paschos, Konstantinos ^{[1
]}

Allday, Martin J. ^{[1
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Virol Sect, Div Infect Dis, Fac Med, London W2 1PG, England

来源：

TRENDS IN MICROBIOLOGY | 2010年 / 18卷 / 10期

基金：

英国惠康基金;

关键词：

EPSTEIN-BARR-VIRUS; HELICOBACTER-PYLORI INFECTION; ABERRANT PROMOTER METHYLATION; DNA METHYLTRANSFERASE DNMT3A; BURKITTS-LYMPHOMA CELLS; TUMOR-SUPPRESSOR LOCUS; H3; LYSINE; 9; HEPATITIS-B; E-CADHERIN; X PROTEIN;

D O I：

10.1016/j.tim.2010.07.003

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

One of the key questions in the study of mammalian gene regulation is how epigenetic methylation patterns on histones and DNA are initiated and established. These stable, heritable, covalent modifications are largely associated with the repression or silencing of gene transcription, and when deregulated can be involved in the development of human diseases such as cancer. This article reviews examples of viruses and bacteria known or thought to induce epigenetic changes in host cells, and how this might contribute to disease. The heritable nature of these processes in gene regulation suggests that they could play important roles in chronic diseases associated with microbial persistence; they might also explain so-called 'hit-and-run' phenomena in infectious disease pathogenesis.

引用

页码：439 / 447

页数：9