Acute interferon-α administration modulates sucrose consumption in the rat

被引:35
作者
Sammut, S [1 ]
Goodall, G
Muscat, R
机构
[1] Univ Malta, Dept Biomed Sci, Lab Behav Neurosci, Msida, Malta
[2] Univ Bordeaux 2, Lab Sci Cognit EA487, Bordeaux, France
关键词
recombinant human interferon-alpha A; recombinant rat interferon; sucrose consumption; anhedonia; depression; sickness behaviour; psychoneuroimmunomodulation;
D O I
10.1016/S0306-4530(00)00051-2
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
One of the two core symptoms of depression as defined by the Diagnostic and statistical manual of mental disorders (DSM-IV) (American Psychiatric Association) is anhedonia, or a loss of interest or pleasure. Sucrose consumption has been described as a valid measure of sensitivity to reward. In the present set of studies, changes in sucrose consumption (three-bottle test using 1, 8 and 32% sucrose) were taken as a measure of the anhedonic effect of interferon-alpha (IFN-alpha). Sucrose tests were carried out following the i.p. administration (20 min pre-treatment time) of Recombinant Human Interferon-alphaA (rHIFN-alpha), 10(1), 10(2), 10(4) units(U) and Rat Interferon alpha (rRIFN-alpha). 1,10 and 100 IRU. Both types of IFN-alpha produced a decrease in sucrose consumption and drinking rate (DR) at the highest doses, with the greatest inhibition being at the lowest sucrose concentration (1%)). Longer pre-treatment times with rHIFN-alpha (40 and 80 min prior to commencement of 1 h drinking test) resulted in insignificant effects. Significant hypothermia relative to vehicle-injected rats was observed following interferon administration in the 20 min pre-treatment condition, but showed no significant difference when compared to vehicle at 40 or 80 min. Overall these results confirm a depression-like behavioural syndrome (anhedonia) following administration of IFN-alpha. (C) 2001 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:261 / 272
页数:12
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