Dynamic Imaging of functionalized multi-walled carbon nanotube systemic circulation and urinary excretion

被引：166

作者：

Lacerda, Lara ^{[1
]}

Soundararajan, Anuradha ^{[2
]}

Singh, Ravi ^{[1
]}

Pastorin, Giorgia ^{[3
]}

Al-Jamal, Khtdoud T. ^{[1
]}

Turton, John ^{[1
]}

Frederik, Peter ^{[4
]}

Herrero, Maria A. ^{[5
]}

Bao, Shouping Li Ande ^{[2
,3
]}

Emfietzoglou, Dimitris ^{[6
]}

Mather, Stephen ^{[7
]}

Phillips, William T. ^{[2
]}

Prato, Maurizio ^{[5
]}

Bianco, Alberto ^{[3
]}

Goins, Beth ^{[2
]}

Kostarelos, Kostas ^{[1
]}

机构：

[1] Univ London, Nanomed Lab, Ctr Drug Delivery Res, Sch Pharm, London WC1N 1AX, England

[2] Univ Texas Hlth Sci Ctr San Antonio, Dept Radiol, San Antonio, TX 78284 USA

[3] CNRS, Inst Biol Mol & Cellulaire, Lab Immunol & Chim Therapeut, F-67084 Strasbourg, France

[4] Univ Maastricht, Sch Med, Electron Microscopy Unit, Maastricht, Netherlands

[5] Univ Trieste, Dipartimento Sci Farmaceut, Trieste, Italy

[6] Univ Ioannina, Sch Med, Dept Med Phys, GR-45110 Ioannina, Greece

[7] St Bartholomews Hosp, Nucl Med Res Lab, London, England

来源：

ADVANCED MATERIALS | 2008年 / 20卷 / 02期

关键词：

D O I：

10.1002/adma.200702334

中图分类号：

O6 [化学];

学科分类号：

0703 [化学];

摘要：

Intravenously administered multi-walled carbon nanotubes, functionalized with DTPA and radiolabeled with Indium-111, were dynamically tracked in vivo using a microSingle Photon Emission Tomography scanner. Imaging showed that nanotubes enter the systemic blood circulation and within 5 min begin to permeate through the renal glomerular filtration system into the bladder.

引用

页码：225 / +

页数：7

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