Broad spectrum chemokine antagonistic activity of a human poxvirus chemokine homolog

被引：99

作者：

Damon, I

Murphy, PM

Moss, B

机构：

[1] NIAID, Viral Dis Lab, NIH, Bethesda, MD 20892 USA

[2] NIAID, Host Def Lab, NIH, Bethesda, MD 20892 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1998年 / 95卷 / 11期

关键词：

D O I：

10.1073/pnas.95.11.6403

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A secreted CC chemokine homolog, encoded by the MC148 gene of molluscum contagiosum virus, potently interfered with the chemotaxis of human monocytes, lymphocytes, and neutrophils in response to a large number of CC and CXC chemokines with diverse receptor specificities. Evidence that the viral protein binds to human chemokine receptors was obtained by competition binding and calcium mobilization experiments. The broad spectrum chemokine antagonistic activity of MC148 can explain the prolonged absence of an inflammatory response in skin tumors that harbor replicating molluscum contagiosum virus.

引用

收藏

页码：6403 / 6407

页数：5

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