Ultrasensitive and selective DNA detection based on nicking endonuclease assisted signal amplification and its application in cancer cell detection

被引：114

作者：

Bi, Sai ^{[1
]}

Zhang, Jilei ^{[1
]}

Zhang, Shusheng ^{[1
]}

机构：

[1] Qingdao Univ Sci & Technol, Coll Chem & Mol Engn, Minist Educ, Key Lab Ecochem Engn, Qingdao 266042, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2010年 / 46卷 / 30期

关键词：

APTAMER-CONJUGATED NANOPARTICLES; NANOTECHNOLOGY; COLLECTION; DNAZYMES; MACHINE; ASSAY;

D O I：

10.1039/c0cc00127a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

By significantly circumventing the typical problem of high background induced by excess hemin itself, an ultrasensitive DNA amplified detection method is developed based on nicking endonuclease (NEase) assisted strand scission cycle, which is further successfully applied in cancer cell detection.

引用

收藏

页码：5509 / 5511

页数：3

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