Single-molecule detection of biomolecules by surface-enhanced coherent anti-Stokes Raman scattering

被引:71
作者
Koo, TW [1 ]
Chan, S [1 ]
Berlin, AA [1 ]
机构
[1] Intel Corp, CTM, Intel Res, Precis Biol, Santa Clara, CA 95054 USA
关键词
D O I
10.1364/OL.30.001024
中图分类号
O43 [光学];
学科分类号
070207 ; 0803 ;
摘要
We report on the applicability of combining surface-enhanced Raman scattering (SERS) with coherent anti-Stokes Raman scattering for high-sensitivity detection of biological molecules. We found that this combination of techniques provides more than 3 orders of signal enhancement compared with SERS and permits monitoring of biological molecules such as deoxyguanosine monophosphate (dGMP) and deoxyadenosine monophosphate at the single-molecule level. This combined technique also improved detection sensitivity for angiotensin peptide. As this is believed to be the first report of detection of dGMP at the single-molecule level, we suggest that this approach can serve as a new tool for biological studies. (c) 2005 Optical Society of America.
引用
收藏
页码:1024 / 1026
页数:3
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