High-sensitivity coherent anti-Stokes Raman scattering microscopy with two tightly synchronized picosecond lasers

被引：153

作者：

Potma, EO ^{[1
]}

Jones, DJ

Cheng, JX

Xie, XS

Ye, J

机构：

[1] Harvard Univ, Dept Chem & Chem Biol, Cambridge, MA 02138 USA

[2] Univ Colorado, Boulder, CO 80309 USA

[3] JILA, Boulder, CO USA

[4] Natl Inst Standards & Technol, Gaithersburg, MD USA

来源：

OPTICS LETTERS | 2002年 / 27卷 / 13期

关键词：

Picosecond lasers;

D O I：

10.1364/OL.27.001168

中图分类号：

O43 [光学];

学科分类号：

070207 ; 0803 ;

摘要：

We demonstrate a significant improvement in signal-to-noise ratio in coherent anti-Stokes Raman scattering (CARS) spectroscopy/microscopy, using two highly synchronized picosecond Ti:sapphire lasers. A temporal jitter between the pulse trains from the two independent commercial lasers is reduced from a few picoseconds to similar to21 fs. maintained over several hours. The tight synchronization brings the fluctuation of the CARS signal down to the shot-noise limit. leading to enhanced CARS vibrational images of living cells and polymer beads. (C) 2002 Optical Society of America.

引用

页码：1168 / 1170

页数：3

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