Cu(II)-nitroxyl radicals as catalytic galactose oxidase mimics

被引：189

作者：

Dijksman, A ^{[1
]}

Arends, IWCE ^{[1
]}

Sheldon, RA ^{[1
]}

机构：

[1] Delft Univ Technol, Dept Biotechnol, Lab Biocatalysis & Organ Chem, NL-2628 BL Delft, Netherlands

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2003年 / 1卷 / 18期

关键词：

D O I：

10.1039/b305941c

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Results from Hammett correlation studies and primary kinetic isotope effects for the CuCl - TEMPO catalysed aerobic benzyl alcohol oxidations are inconsistent with an oxoammonium based mechanism. We postulate a copper-mediated dehydrogenation mechanism, in which TEMPO regenerates the active Cu(II)-species. This mechanism is analogous to that observed for Galactose Oxidase and mimics thereof.

引用

页码：3232 / 3237

页数：6

共 43 条

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