IL-17 in obesity and adipogenesis

被引:140
作者
Ahmed, Mushtaq [1 ]
Gaffen, Sarah L. [1 ]
机构
[1] Univ Pittsburgh, Dept Med, Div Clin Immunol & Rheumatol, Pittsburgh, PA 15261 USA
关键词
Interleukin-17; Th17; Adipogenesis; Mesenchymal stem cell; NECROSIS-FACTOR-ALPHA; ADIPOSE-TISSUE; INTERLEUKIN-17; FAMILY; INSULIN-RESISTANCE; CELLS; INFLAMMATION; LEPTIN; DIFFERENTIATION; EXPRESSION; ADIPOCYTE;
D O I
10.1016/j.cytogfr.2010.10.005
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The pro-inflammatory cytokine interleukin (IL)-17 (also known as IL-17) has been associated with induction of tissue inflammation. Obese individuals exhibit many symptoms of chronic low-grade inflammation, suggesting that IL-17 may impact adipose tissue. However, the role of IL-17 in obesity is largely unexplored. Emerging studies indicate that obesity selectively promotes expansion of the Th17 T-cell lineage, exacerbating disease in murine models of autoimmunity such as EAE and colitis. Human studies support this concept, as new clinical studies suggest that IL-17 is expressed at elevated levels in obese individuals. Conversely, however, an anti-adipogenic role for IL-17 is becoming evident, and therefore the interconnections between IL-17 and fat metabolism may be quite complex. Here, we consolidate the potential implications of IL-17 in relation to obesity and describe the emerging data regarding the role of IL-17 in adipose tissue. (C) 2010 Elsevier Ltd. All rights reserved.
引用
收藏
页码:449 / 453
页数:5
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