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IL-17 in obesity and adipogenesis
被引:140
作者:
Ahmed, Mushtaq
[1
]
Gaffen, Sarah L.
[1
]
机构:
[1] Univ Pittsburgh, Dept Med, Div Clin Immunol & Rheumatol, Pittsburgh, PA 15261 USA
关键词:
Interleukin-17;
Th17;
Adipogenesis;
Mesenchymal stem cell;
NECROSIS-FACTOR-ALPHA;
ADIPOSE-TISSUE;
INTERLEUKIN-17;
FAMILY;
INSULIN-RESISTANCE;
CELLS;
INFLAMMATION;
LEPTIN;
DIFFERENTIATION;
EXPRESSION;
ADIPOCYTE;
D O I:
10.1016/j.cytogfr.2010.10.005
中图分类号:
Q5 [生物化学];
Q7 [分子生物学];
学科分类号:
071010 ;
081704 ;
摘要:
The pro-inflammatory cytokine interleukin (IL)-17 (also known as IL-17) has been associated with induction of tissue inflammation. Obese individuals exhibit many symptoms of chronic low-grade inflammation, suggesting that IL-17 may impact adipose tissue. However, the role of IL-17 in obesity is largely unexplored. Emerging studies indicate that obesity selectively promotes expansion of the Th17 T-cell lineage, exacerbating disease in murine models of autoimmunity such as EAE and colitis. Human studies support this concept, as new clinical studies suggest that IL-17 is expressed at elevated levels in obese individuals. Conversely, however, an anti-adipogenic role for IL-17 is becoming evident, and therefore the interconnections between IL-17 and fat metabolism may be quite complex. Here, we consolidate the potential implications of IL-17 in relation to obesity and describe the emerging data regarding the role of IL-17 in adipose tissue. (C) 2010 Elsevier Ltd. All rights reserved.
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页码:449 / 453
页数:5
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