IL-17 in Systemic Lupus Erythematosus

被引：76

作者：

Crispin, Jose C. ^{[1
]}

Tsokos, George C. ^{[1
]}

机构：

[1] Harvard Univ, Beth Israel Deaconess Med Ctr, Sch Med, Dept Med, Boston, MA 02130 USA

来源：

JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY | 2010年

关键词：

PLASMACYTOID DENDRITIC CELLS; COLONY-STIMULATING FACTOR; REGULATORY T-CELLS; PATHOGENIC AUTOANTIBODIES; NEUTROPHIL RECRUITMENT; LASER MICRODISSECTION; CHEMOKINE PRODUCTION; TH17; CELLS; BXD2; MICE; TGF-BETA;

D O I：

10.1155/2010/943254

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

IL-17 is a cytokine with powerful proinflammatory activity. Production of IL-17 is abnormally increased in patients with systemic lupus erythematosus (SLE), a multiorgan chronic autoimmune disease. In patients with SLE, CD3(+)CD4(-)CD8(-) (double negative) T cells are an important source of IL-17. IL-17 produced by double negative and CD4 T cells participates in the pathogenesis of the disease. IL-17-producing T cells are present in the kidneys of patients with lupus nephritis. IL-17 increased production in patients with SLE can amplify the immune response by increasing target organ inflammation and damage and by augmenting the production of antibodies by B cells.

引用

页数：4

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