Transient increased extracellular release of H2O2 during establishment of UVB-induced premature senescence

被引：10

作者：

Borlon, Celine ^{[1
]}

Chretien, Aline ^{[1
]}

Debacq-Chainiaux, Florence ^{[1
]}

Toussaint, Olivier ^{[1
]}

机构：

[1] Univ Namur, FUNDP, Fac Sci, Dept Biol,Res Unit Cellular Biol URBC, B-5000 Namur, Belgium

来源：

MOLECULAR MECHANISMS AND MODELS OF AGING | 2007年 / 1119卷

关键词：

UVB; H2O2; catalase; glutathione peroxidase; fibroblasts;

D O I：

10.1196/annals.1404.002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

In this work, we found that extracellular release of H2O2 is 1.5- to 6-fold higher in skin human diploid fibroblasts exposed to UVB in conditions inducing premature senescence when compared to control cells without exposure to UVB. The apparent decrease in H2O2 production from 0 to 72 h after the last exposure to UVB was not due to increased enzymatic activity of catalase or glutathione peroxidase.

引用

收藏

页码：72 / 77

页数：6

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