Presynaptic γ-aminobutyric acid type B receptor-mediated regulation of vesicular γ-aminobutyric acid transporter expression in the gerbil hippocampus

被引：12

作者：

Kang, TC ^{[1
]}

Park, SK ^{[1
]}

Hwang, IK ^{[1
]}

An, SJ ^{[1
]}

Won, MH ^{[1
]}

机构：

[1] Hallym Univ, Coll Med, Dept Anat, Chunchon 200702, Kangwon Do, South Korea

来源：

NEUROSCIENCE LETTERS | 2003年 / 346卷 / 1-2期

关键词：

gamma-aminobutyric acid type B receptor; epilepsy; gerbil; hippocampus; vesicular gamma-aminobutyric acid transporter; gamma-aminobutyric acid;

D O I：

10.1016/S0304-3940(03)00560-3

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Changes in vesicular gamma-aminobutyric acid (GABA) transporter (VGAT) expression in the gerbil hippocampus after treatment with baclofen (GABA(B) receptor agonist) or phaclofen (GABAB receptor antagonist) were investigated to identify the GABAB receptor-mediated regulation of VGAT expression. In the baclofen-treated seizure-resistant gerbils, VGAT expression was significantly reduced, as compared with the control animals, thus the VGAT immunoreactive pattern in these gerbils was similar to that in control seizure-sensitive (SS) gerbils. In the phaclofen-treated SS gerbils, VGAT expression was dramatically elevated, compared to SS gerbil controls. Our findings demonstrated that GABAB receptor-mediated regulation of VGAT expression may be another mechanisms for presynaptic GABA release, which is accompanied by a reduction in Ca2+ conductance by the inhibition of voltage-gated Ca2+ channels. (C) 2003 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：49 / 52

页数：4

共 15 条

[1] γ-aminobutyric acid type B receptor splice variant proteins GBR1a and GBR1b are both associated with GBR2 in situ and display differential regional and subcellular distribution [J].

Benke, D ;

Honer, M ;

Michel, C ;

Bettler, B ;

Mohler, H .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (38) :27323-27330

[2] GABAB receptors:: drugs meet clones [J].

Bettler, B ;

Kaupmann, K ;

Bowery, N .

CURRENT OPINION IN NEUROBIOLOGY, 1998, 8 (03) :345-350

[3]

Haas KZ, 1996, J NEUROSCI, V16, P4250

[4] Reversal of the activity-dependent suppression of GABA-mediated inhibition in hippocampal slices from γ-vinyl GABA (vigabatrin)-pretreated rats [J].

Jackson, MF ;

Esplin, B ;

Capek, R .

NEUROPHARMACOLOGY, 2000, 39 (01) :65-74

[5] Demonstration of functional coupling between γ-aminobutyric acid (GABA) synthesis and vesicular GABA transport into synaptic vesicles [J].

Jin, H ;

Wu, H ;

Osterhaus, G ;

Wei, JN ;

Davis, K ;

Sha, D ;

Floor, E ;

Hsu, CC ;

Kopke, RD ;

Wu, JY .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (07) :4293-4298

[6] Changed vesicular GABA transporter immunoreactivity in the gerbil hippocampus following spontaneous seizure and vigabatrin administration [J].

Kang, TC ;

An, SJ ;

Park, SK ;

Hwang, IK ;

Bae, JC ;

Won, MH .

NEUROSCIENCE LETTERS, 2003, 335 (03) :207-211

[7] The temporal alteration of GAD67/GAD65 ratio in the gerbil hippocampal complex following seizure [J].

Kang, TC ;

Kim, HS ;

Seo, MO ;

Choi, SY ;

Kwon, OS ;

Baek, NI ;

Lee, HY ;

Won, MH .

BRAIN RESEARCH, 2001, 920 (1-2) :159-169

[8] INCREASED ENKEPHALIN AND DYNORPHIN IMMUNOREACTIVITY IN THE HIPPOCAMPUS OF SEIZURE SENSITIVE MONGOLIAN GERBILS [J].

LEE, RJ ;

HONG, JS ;

MCGINTY, JF ;

LOMAX, P .

BRAIN RESEARCH, 1987, 401 (02) :353-358

[9] GERBIL AS A MODEL FOR STUDY OF EPILEPSIES - SEIZURE PATTERNS AND ONTOGENESIS [J].

LOSKOTA, WJ ;

LOMAX, P ;

RICH, ST .

EPILEPSIA, 1974, 15 (01) :109-119

[10]

MCDONALD BJ, 1994, J BIOL CHEM, V269, P18111

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