Lymphocyte activation by CpG dinucleotide motifs in prokaryotic DNA

被引：106

作者：

Krieg, AM

机构：

[1] UNIV IOWA,COLL MED,DEPT INTERNAL MED,IOWA CITY,IA 52242

[2] VET AFFAIRS MED CTR,IOWA CITY,IA 52246

来源：

TRENDS IN MICROBIOLOGY | 1996年 / 4卷 / 02期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/0966-842X(96)81515-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

CpG dinucleotides are present at the expected frequency in prokaryotic DNA, but are underrepresented ('CpG suppression') and methylated in vertebrate DNA. The vertebrate immune system has apparently evolved the ability to recognize these unmethylated CpG motifs and respond with a rapid and coordinated cytokine response leading to the induction of humoral and cell-mediated immunity.

引用

收藏

页码：73 / 77

页数：5

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