Medicinal chemistry and biological properties of non-imidazole histamine H3 antagonists

被引：68

作者：

Cowart, M ^{[1
]}

Altenbach, R ^{[1
]}

Black, L ^{[1
]}

Faghih, R ^{[1
]}

Zhao, C ^{[1
]}

Hancock, AA ^{[1
]}

机构：

[1] Abbott Labs, Dept Neurosci Res, Round Lake, IL 60073 USA

来源：

MINI-REVIEWS IN MEDICINAL CHEMISTRY | 2004年 / 4卷 / 09期

关键词：

non-imidazole; histamine; H-3; review; antagonist; inverse agonist;

D O I：

10.2174/1389557043403215

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The H-3 receptor is prominently expressed in neuronal tissues, and H-3 antagonists have been proposed as drugs with benefits in disorders of cognition, attention, pain, allergic rhinitis, and obesity. The structure-activity relationships (SAR) of various classes of non-imidazole H-3 antagonists are reviewed, along with highlights of functional efficacy in tissue-based and animal disease models.

引用

页码：979 / 992

页数：14

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