RNAi: The nuts and bolts of the RISC machine

被引：379

作者：

Filipowicz, W ^{[1
]}

机构：

[1] Friedrich Miescher Inst, CH-4058 Basel, Switzerland

来源：

CELL | 2005年 / 122卷 / 01期

关键词：

D O I：

10.1016/j.cell.2005.06.023

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Research on RNA interference and microRNA pathways continues to accelerate. Combinations of biochemical, genetic, and structural approaches are providing new insights into the mechanism by which small, 21 nt long RNAs find their way into the RISC effector complexes and how the RISCs execute their mission of RNA-guided posttranscriptional gene silencing.

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页码：17 / 20

页数：4

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