Silica-based monoliths for capillary electrochromatography: Methods of fabrication and their applications in analytical separations

被引:103
作者
Allen, D [1 ]
El Rassi, Z [1 ]
机构
[1] Oklahoma State Univ, Dept Chem, Stillwater, OK 74078 USA
关键词
capillary electrochromatography; review; silica-based monoliths;
D O I
10.1002/elps.200305669
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
This review article is intended to provide the reader with the recent advances made in the fabrication of silica-based monolithic capillary columns for use in capillary electrochromatography (CEC). The silica-based monoliths can be produced by three different approaches, namely (i) fusion of silica particles by thermal sintering, (ii) cross-linking/ entrapping silica particles in a packed bed using the sol-gel process, and (iii) polymerization of silicon alkoxide precursors using the sol-gel process. Thus far, approach (iii) is the most widely used for fabricating silica monoliths. After providing a thorough description of each of the three approaches used for the production of silica-based monolithic capillary columns, the analytical separations performed by CEC on each kind of monolith are discussed.
引用
收藏
页码:3962 / 3976
页数:15
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