Identification of the mammalian homologues of the Drosophila timeless gene, Timeless1

被引：63

作者：

Koike, N ^{[1
]}

Hida, A ^{[1
]}

Numano, R ^{[1
]}

Hirose, M ^{[1
]}

Sakaki, Y ^{[1
]}

Tei, H ^{[1
]}

机构：

[1] Univ Tokyo, Inst Med Sci, Ctr Human Genome, Minato Ku, Tokyo, Japan

来源：

FEBS LETTERS | 1998年 / 441卷 / 03期

关键词：

circadian rhythm; timeless homologue; mammalian clock gene;

D O I：

10.1016/S0014-5793(98)01597-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We have identified novel mammalian homologues of a Drosophila clock gene, timeless, and designated them as human TIMELESS1 (hTIM1) and mouse Timeless1 (mTim1), respectively. These genes mere mapped by FISH to chromosomal regions 12q12-13 in human and 10D3 in mouse. The deduced amino acid sequences of hTim1 and mTim1 proteins mere 1208 and 1197 amino acids in length and shared 83% identity. Northern blot analysis identified a single transcript of 4.5 kb expressed widely in many tissues examined. Unlike the Drosophila counterpart, the levels of the mTim1 transcript exhibited no prominent circadian oscillation in the mouse brain. (C) 1998 Federation of European Biochemical Societies.

引用

页码：427 / 431

页数：5

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