ppGpp: magic beyond RNA polymerase

被引：333

作者：

Dalebroux, Zachary D. ^{[2
]}

Swanson, Michele S. ^{[1
]}

机构：

[1] Univ Michigan, Sch Med, Dept Microbiol & Immunol, Ann Arbor, MI 48109 USA

[2] Univ Washington, Dept Microbiol, Seattle, WA 98195 USA

来源：

NATURE REVIEWS MICROBIOLOGY | 2012年 / 10卷 / 03期

基金：

美国国家卫生研究院;

关键词：

BINDING PROTEIN CSRA; C-DI-GMP; GENERAL STRESS-RESPONSE; ESCHERICHIA-COLI; INORGANIC POLYPHOSPHATE; STRINGENT RESPONSE; MESSENGER-RNA; POLYNUCLEOTIDE PHOSPHORYLASE; LISTERIA-MONOCYTOGENES; SIGNAL-TRANSDUCTION;

D O I：

10.1038/nrmicro2720

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

During stress, bacteria undergo extensive physiological transformations, many of which are coordinated by ppGpp. Although ppGpp is best known for enhancing cellular resilience by redirecting the RNA polymerase (RNAP) to certain genes, it also acts as a signal in many other cellular processes in bacteria. After a brief overview of ppGpp biosynthesis and its impact on promoter selection by RNAP, we discuss how bacteria exploit ppGpp to modulate the synthesis, stability or activity of proteins or regulatory RNAs that are crucial in challenging environments, using mechanisms beyond the direct regulation of RNAP activity.

引用

页码：203 / 212

页数：10

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