Fluorescence optical diffusion tomography

被引：234

作者：

Milstein, AB ^{[1
]}

Oh, S

Webb, KJ

Bouman, CA

Zhang, Q

Boas, DA

Millane, RP

机构：

[1] Purdue Univ, Sch Elect & Comp Engn, W Lafayette, IN 47907 USA

[2] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Nucl Magnet Resonance Ctr, Charlestown, MA 02129 USA

[3] Univ Canterbury, Dept Elect & Comp Engn, Christchurch, New Zealand

来源：

APPLIED OPTICS | 2003年 / 42卷 / 16期

关键词：

D O I：

10.1364/AO.42.003081

中图分类号：

O43 [光学];

学科分类号：

070207 ; 0803 ;

摘要：

A nonlinear, Bayesian optimization scheme is presented for reconstructing fluorescent yield and lifetime, the absorption coefficient, and the diffusion coefficient in turbid media, such as biological tissue. The method utilizes measurements at both the excitation and the emission wavelengths to reconstruct all unknown parameters. The effectiveness of the reconstruction algorithm is demonstrated by simulation and by application to experimental data from a tissue phantom containing the fluorescent agent Indocyanine Green. (C) 2003 Optical Society of America.

引用

页码：3081 / 3094

页数：14

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