Immunology of hepatitis B virus and hepatitis C virus infection

被引：1299

作者：

Rehermann, B ^{[1
]}

Nascimbeni, M ^{[1
]}

机构：

[1] NIDDKD, Liver Res Branch, NIH, Bethesda, MD 20892 USA

来源：

NATURE REVIEWS IMMUNOLOGY | 2005年 / 5卷 / 03期

关键词：

D O I：

10.1038/nri1573

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

More than 500 million people worldwide are persistently infected with the hepatitis B virus (HBV) and/or hepatitis C virus (HCV) and are at risk of developing chronic liver disease, cirrhosis and hepatocellular carcinoma. Despite many common features in the pathogenesis of HBV- and HCV-related liver disease, these viruses markedly differ in their virological properties and in their immune escape and survival strategies. This review assesses recent advances in our understanding of viral hepatitis, contrasts mechanisms of virus - host interaction in acute hepatitis B and hepatitis C, and outlines areas for future studies.

引用

页码：215 / 229

页数：15

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