Stage-specific changes in gene expression in acutely isolated mouse CNS progenitor cells

被引：40

作者：

Abramova, N ^{[1
]}

Charniga, C ^{[1
]}

Goderie, SK ^{[1
]}

Temple, S ^{[1
]}

机构：

[1] Albany Med Coll, Ctr Neuropharmacol & Neurosci, Albany, NY 12208 USA

来源：

DEVELOPMENTAL BIOLOGY | 2005年 / 283卷 / 02期

关键词：

neural stem cells; neural progenitor cells; LeX; CD15; gene expression analysis;

D O I：

10.1016/j.ydbio.2005.03.040

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Neural progenitor cells can be derived from a variety of developmental stages when they are preferentially proliferating, undergoing neurogenesis or undergoing gliogenesis. We used FACS sorting and the LeX surface marker to enrich neural progenitor cells from different embryonic stages and adult and compared their gene expression profiles using Affymetrix Microarrays. Our results show that, while there are common genes expressed in the progenitor cell population from all stages, there are also significant differences in gene expression patterns that correlate with stage-related behaviors. These data indicate that progenitor cells change during development and that adult and embryonic neural progenitor cells are intrinsically different. (c) 2005 Elsevier Inc. All rights reserved.

引用

页码：269 / 281

页数：13

共 67 条

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