Portrait of a stem cell

被引:37
作者
Burns, CE [1 ]
Zon, LI [1 ]
机构
[1] Childrens Hosp, Howard Hughes Med Inst, Dept Hematol Oncol, Boston, MA 02115 USA
关键词
D O I
10.1016/S1534-5807(02)00329-5
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
There is great enthusiasm for the potential use of stem cells in treating tissue degenerative disorders, but little is known about the intrinsic molecular programs defining self-renewal and differentiation. New data sets produced by transcriptional profiling of purified stem cell populations begin to establish the nature of "sternness."
引用
收藏
页码:612 / 613
页数:2
相关论文
共 10 条
  • [1] A molecular profile of a hematopoietic stem cell niche
    Hackney, JA
    Charbord, P
    Brunk, BP
    Stoeckert, CJ
    Lemischka, IR
    Moore, KA
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (20) : 13061 - 13066
  • [2] A stem cell molecular signature
    Ivanova, NB
    Dimos, JT
    Schaniel, C
    Hackney, JA
    Moore, KA
    Lemischka, IR
    [J]. SCIENCE, 2002, 298 (5593) : 601 - 604
  • [3] Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4
    Korinek, V
    Barker, N
    Moerer, P
    van Donselaar, E
    Huls, G
    Peters, PJ
    Clevers, H
    [J]. NATURE GENETICS, 1998, 19 (04) : 379 - 383
  • [4] Lawrence H. J., 2001, HEMATOPOIESIS DEV AP, P402
  • [5] MAY G, 2001, HEMATOPOIESIS DEV AP, P61
  • [6] Hematopoiesis and stem cells:: plasticity versus developmental heterogeneity
    Orkin, SH
    Zon, LI
    [J]. NATURE IMMUNOLOGY, 2002, 3 (04) : 323 - 328
  • [7] The genetic program of hematopoietic stem cells
    Phillips, RL
    Ernst, RE
    Brunk, B
    Ivanova, N
    Mahan, MA
    Deanehan, JK
    Moore, KA
    Overton, GC
    Lemischka, IR
    [J]. SCIENCE, 2000, 288 (5471) : 1635 - 1640
  • [8] Stemness: Transcriptional profiling of embryonic and adult stem cells
    Ramalho-Santos, M
    Yoon, S
    Matsuzaki, Y
    Mulligan, RC
    Melton, DA
    [J]. SCIENCE, 2002, 298 (5593) : 597 - 600
  • [9] Stem cells find their niche
    Spradling, A
    Drummond-Barbosa, D
    Kai, T
    [J]. NATURE, 2001, 414 (6859) : 98 - 104
  • [10] DIRECT MEASUREMENT OF RADIATION SENSITIVITY OF NORMAL MOUSE BONE MARROW CELLS
    TILL, JE
    MCCULLOCH, EA
    [J]. RADIATION RESEARCH, 1961, 14 (02) : 213 - &