Stemness: Transcriptional profiling of embryonic and adult stem cells

被引：1294

作者：

Ramalho-Santos, M

Yoon, S

Matsuzaki, Y

Mulligan, RC

Melton, DA ^{[1
]}

机构：

[1] Harvard Univ, Dept Mol & Cellular Biol, Cambridge, MA 02138 USA

[2] Harvard Univ, Howard Hughes Med Inst, Cambridge, MA 02138 USA

[3] Harvard Univ, Sch Med, Dept Genet, Boston, MA 02115 USA

来源：

SCIENCE | 2002年 / 298卷 / 5593期

关键词：

D O I：

10.1126/science.1072530

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The transcriptional profiles of mouse embryonic, neural, and hematopoietic stem cells were compared to de ne a genetic program for stem cells. A total of 216 genes are enriched in all three types of stem cells, and several of these genes are clustered in the genome. When compared to differentiated cell types, stem cells express a significantly higher number of genes ( represented by expressed sequence tags) whose functions are unknown. Embryonic and neural stem cells have many similarities at the transcriptional level. These results provide a foundation for a more detailed understanding of stem cell biology.

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收藏

页码：597 / 600

页数：5

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