Stem cells find their niche

被引：1050

作者：

Spradling, A ^{[1
]}

Drummond-Barbosa, D ^{[1
]}

Kai, T ^{[1
]}

机构：

[1] Carnegie Inst Sci, Dept Embryol, HHMI, Baltimore, MD 21210 USA

来源：

NATURE | 2001年 / 414卷 / 6859期

关键词：

D O I：

10.1038/35102160

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The concept that stem cells are controlled by particular microenvironments known as 'riches' has been widely invoked. But niches have remained largely a theoretical construct because of the difficulty of identifying and manipulating individual stem cells and their surroundings. Technical advances now make it possible to characterize small zones that maintain and control stem cell activity in several organs, including gonads, skin and gut. These studies are beginning to unify our understanding of stem cell regulation at the cellular and molecular levels, and promise to advance efforts to use stem cells therapeutically.

引用

页码：98 / 104

页数：7

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