Stem cells find their niche

被引：1050

作者：

Spradling, A ^{[1
]}

Drummond-Barbosa, D ^{[1
]}

Kai, T ^{[1
]}

机构：

[1] Carnegie Inst Sci, Dept Embryol, HHMI, Baltimore, MD 21210 USA

来源：

NATURE | 2001年 / 414卷 / 6859期

关键词：

D O I：

10.1038/35102160

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The concept that stem cells are controlled by particular microenvironments known as 'riches' has been widely invoked. But niches have remained largely a theoretical construct because of the difficulty of identifying and manipulating individual stem cells and their surroundings. Technical advances now make it possible to characterize small zones that maintain and control stem cell activity in several organs, including gonads, skin and gut. These studies are beginning to unify our understanding of stem cell regulation at the cellular and molecular levels, and promise to advance efforts to use stem cells therapeutically.

引用

页码：98 / 104

页数：7

共 86 条

[51] Role of the ZWILLE gene in the regulation of central shoot meristem cell fate during Arabidopsis embryogenesis [J].

Moussian, B ;

Schoof, H ;

Haecker, A ;

Jürgens, G ;

Laux, T .

EMBO JOURNAL, 1998, 17 (06) :1799-1809

[52] EXPRESSION OF A DOMINANT-NEGATIVE MUTANT OF EPIDERMAL GROWTH-FACTOR RECEPTOR IN THE EPIDERMIS OF TRANSGENIC MICE ELICITS STRIKING ALTERATIONS IN HAIR FOLLICLE DEVELOPMENT AND SKIN-STRUCTURE [J].

MURILLAS, R ;

LARCHER, F ;

CONTI, CJ ;

SANTOS, M ;

ULLRICH, A ;

JORCANO, JL .

EMBO JOURNAL, 1995, 14 (21) :5216-5223

[53] Pattern and kinetics of mouse donor spermatogonial stem cell colonization in recipient testes [J].

Nagano, M ;

Avarbock, MR ;

Brinster, RL .

BIOLOGY OF REPRODUCTION, 1999, 60 (06) :1429-1436

[54] Polyclonal origin of colonic adenomas in an XO/XY patient with FAP [J].

Novelli, MR ;

Williamson, JA ;

Tomlinson, IPM ;

Elia, G ;

Hodgson, SV ;

Talbot, IC ;

Bodmer, WF ;

Wright, NA .

SCIENCE, 1996, 272 (5265) :1187-1190

[55]

Ohlstein B, 2000, GENETICS, V155, P1809

[56]

Ohta H, 2000, DEVELOPMENT, V127, P2125

[57] Morphogenesis and renewal of hair follicles from adult multipotent stem cells [J].

Oshima, H ;

Rochat, A ;

Kedzia, C ;

Kobayashi, K ;

Barrandon, Y .

CELL, 2001, 104 (02) :233-245

[58] Towards defining the pathogenesis of the hairless phenotype [J].

Panteleyev, AA ;

van der Veen, C ;

Rosenbach, T ;

Müller-Röver, S ;

Sokolov, VE ;

Paus, R .

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1998, 110 (06) :902-907

[59] Development of germ cell transplants in mice [J].

Parreira, GG ;

Ogawa, T ;

Avarbock, MR ;

França, LR ;

Brinster, RL ;

Russell, LD .

BIOLOGY OF REPRODUCTION, 1998, 59 (06) :1360-1370

[60] Conditional ablation of β1 integrin in skin:: Severe defects in epidermal proliferation, basement membrane formation, and hair follicle invagination [J].

Raghavan, S ;

Bauer, C ;

Mundschau, G ;

Li, QQ ;

Fuchs, E .

JOURNAL OF CELL BIOLOGY, 2000, 150 (05) :1149-1160

← 1 2 3 4 5 6 7 8 9 →