The promise of genetically engineered mice for cancer prevention studies

被引：64

作者：

Green, JE ^{[1
]}

Hudson, T ^{[1
]}

机构：

[1] NCI, Transgen Oncogenesis Grp, Lab Cell Regulat & Carcinogenesis, Bethesda, MD 20892 USA

来源：

NATURE REVIEWS CANCER | 2005年 / 5卷 / 03期

关键词：

D O I：

10.1038/nrc1565

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Sophisticated genetic technologies have led to the development of mouse models of human cancers that recapitulate important features of human oncogenesis. Many of these genetically engineered mouse models promise to be very relevant and relatively rapid systems for determining the efficacy of chemopreventive agents and their mechanisms of action. The validation of such models for chemoprevention will help the selection of appropriate agents for large-scale clinical trials and allow the testing of combination therapies.

引用

页码：184 / 198

页数：15

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