Stereoselective synthesis of conformationally constrained reverse turn dipeptide mimetics

被引：84

作者：

Qiu, W ^{[1
]}

Gu, XY ^{[1
]}

Soloshonok, VA ^{[1
]}

Carducci, MD ^{[1
]}

Hruby, VJ ^{[1
]}

机构：

[1] Univ Arizona, Dept Chem, Tucson, AZ 85721 USA

来源：

TETRAHEDRON LETTERS | 2001年 / 42卷 / 02期

关键词：

D O I：

10.1016/S0040-4039(00)01864-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Peptide side chains play critical roles in the event of molecular recognition. In order to study the bioactive conformation of parent peptides, a concise and straightforward five-step synthesis of [5.5]-bicyclic reverse turn dipeptide mimetic scaffolds with side chain functionality at the i+1 and i+2 positions has been developed. In the bicyclic structure, two dihedral angles (psi (2) and phi (3)) are greatly restricted. (C) 2000 Elsevier Science Ltd. All rights reserved.

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页码：145 / 148

页数：4

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