Synthesis of Highly Fluorinated 2,2′-Biphenols and 2,2′-Bisanisoles

被引：12

作者：

Francke, Robert ^{[1
,2
]}

Schnakenburg, Gregor ^{[3
]}

Waldvogel, Siegfried R. ^{[1
,2
]}

机构：

[1] Univ Bonn, Kekule Inst Organ Chem & Biochem, D-53121 Bonn, Germany

[2] Johannes Gutenberg Univ Mainz, Inst Organ Chem, D-55128 Mainz, Germany

[3] Univ Bonn, Inst Inorgan Chem, Xray Anal Dept, D-53121 Bonn, Germany

来源：

ORGANIC LETTERS | 2010年 / 12卷 / 19期

关键词：

COUPLING REACTION; DERIVATIVES; F8BINOL;

D O I：

10.1021/ol101698a

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Multiply fluorine-substituted iodo anisoles are efficiently coupled in an Ullmann-type reaction to provide the corresponding bisanisoles. The coupling is selective and even tolerates bromo moieties. Subsequent deprotection of hydroxy groups gives access to highly fluorinated biphenols.

引用

页码：4288 / 4291

页数：4

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