Efficient and Reliable Iodination and O-Methylation of Fluorinated Phenols

被引：13

作者：

Francke, Robert ^{[1
]}

Schnakenburg, Gregor ^{[2
]}

Waldvogel, Siegfried R. ^{[1
]}

机构：

[1] Univ Bonn, Kekule Inst Organ Chem & Biochem, D-53121 Bonn, Germany

[2] Univ Bonn, Xray Anal Dept, Inst Inorgan Chem, D-53121 Bonn, Germany

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2010年 / 2010卷 / 12期

关键词：

Iodination; Phenols; Oxidation; Alkylation; Fluorinated compounds; DEHYDRODIMERIZATION;

D O I：

10.1002/ejoc.201000161

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Fluorinated phenols and other electron-deficient phenolic substrates are efficiently and cleanly iodinated by an iodine/iodide mixture employing alkaline conditions. This protocol turned out to be the most practical for the generation of such highly fluorinated iodophenols. For later application in coupling processes the protection of the phenolic hydroxy moiety is often required. Therefore, a practical iodination and subsequent methylation sequence was elaborated providing the highly fluorinated anisoles with good to excellent yields. The developed method is applicable for a broad scope of fluorinated phenols and analogues.

引用

页码：2357 / 2362

页数：6

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