Inhibition Of Tumorigenesis in ApcMin/+ Mice by a Combination of (-)-Epigallocatechin-3-gallate and Fish Oil

被引：38

作者：

Bose, Mousumi ^{[1
]}

Hao, Xingpei ^{[1
]}

Ju, Jihyeung ^{[1
]}

Husain, Ali ^{[1
]}

Park, Sunny ^{[1
]}

Lambert, Joshua D. ^{[1
]}

Yang, Chung S. ^{[1
]}

机构：

[1] State Univ New Jersey, Ernest Mario Sch Pharm, Dept Chem biol, Susan L Cullman Lab Canc Res, Piscataway, NJ 08554 USA

来源：

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY | 2007年 / 55卷 / 19期

关键词：

(-)-Epigallocatechin gallate; fish oil; Apc(Min/+); mouse; intestinal cancer;

D O I：

10.1021/jf071004r

中图分类号：

S [农业科学];

学科分类号：

09 ;

摘要：

The effect of a combination of (-)-epigallocatechin-3-gallate (EGCG) with fish oil on intestinal tumorigenesis in Apc(Min/+) mice fed a high-fat diet was investigated in the present study. The combined treatment of EGCG and fish oil for 9 weeks reduced the tumor number by 53% as compared to controls while neither agent alone had a significant effect. Apoptosis was significantly increased in all treatment groups. beta-Catenin nuclear positivity in adenomas from the combination group was lower than control mice, implicating the modulation of Wnt signaling by the combination. Fish oil and the combination significantly reduced prostaglandin E-2 (PGE(2)) levels in small intestinal tumors as compared to controls, suggesting modulation of aberrant arachidonic acid metabolism by fish oil. Akt phosphorylation in adenomas was significantly reduced in all treatment groups, which may have contributed to the observed increase in apoptosis. The results indicate that a combination of low doses of EGCG and fish oil can inhibit tumor multiplicity in Apc(Min/+) mice.

引用

页码：7695 / 7700

页数：6

共 41 条

[21] Response of Apcmin and A33ΔNβ-cat mutant mice to treatment with tea, sulindac, and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) [J].