Direct magnesiation of polyfunctionalized arenes and heteroarenes using (tmp)2Mg-2LiCl

被引：184

作者：

Clososki, Giuliano C. ^{[1
]}

Rohbogner, Christoph J. ^{[1
]}

Knochel, Paul ^{[1
]}

机构：

[1] Univ Munich, Dept Chem, D-81377 Munich, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2007年 / 46卷 / 40期

关键词：

copper; cross-coupling; homogeneous catalysis; lithium chloride; organomagnesium compounds;

D O I：

10.1002/anie.200701487

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) Outstripping lithium bases: A wide range of polyfunctional aryl and heteroaryl magnesium reagents were efficiently prepared in THF by direct magnesiation with (tmp)2Mg·2 LiCl, an exceptionally active base. These compounds can serve as intermediates in natural product synthesis. In the example shown a palladium-catalyzed cross-coupling reaction is used to prepare a derivative of salicylic acid. © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.

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页码：7681 / 7684

页数：4

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