Laser dosimetry studies in the prostate

Objective: To review the currently available data of photodynamic therapy (PDT) optical dosimetry for possible prostatic applications, Summary Background Data: PDT is a new cancer treatment modality often used as an alternative tumor treatment method. Recently, PDT has been suggested as an alternative therapy for prostatic carcinoma and BPH, Methods: PDT utilizes light and a preadministered photosensitizer drug to achieve localized tumor control, This article reviews currently available data on optical dosimetry of PDT in both human and canine prostates. Results: At 630 nm, a common wavelength used for Photofrin PDT, results indicate that light penetration is similar in cancerous and normal prostatic tissue. Because of limited light penetration, multiple fiber irradiation is necessary if eradicating the entire prostate gland is the ultimate goal. The available data also show that dynamic changes occur in light fluence rate distribution during PDT irradiation. Conclusions: PDT can be used to destroy prostatic tissue, Real-time optical dosimetry is necessary if accurate lesion volume control is desired.