Microchip-based electrochromatography: designs and applications

被引：78

作者：

Pumera, M ^{[1
]}

机构：

[1] Univ Autonoma Barcelona, Dept Chem, E-08193 Barcelona, Spain

来源：

TALANTA | 2005年 / 66卷 / 04期

关键词：

electrochromatography; microchip; miniaturization; coating; packing material; monolith; DNA; peptides; review;

D O I：

10.1016/j.talanta.2005.01.006

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Different techniques and methods of electrochromatography on "lab on a chip" devices are reviewed. Described approaches include open-channel microchip electrochromatography relying on C-8, C-18 and novel gold nanoparticle (GNP) coating of microchannel wall; packed-channel microchip electrochromatography with new ways of automated loading and unloading of conventional octadecylsilica beads; monolith-based microchip electrochromatography with tailored casting of stationary phase at the specific places of microfluidic network and novel photolitographically fabricated collocated monolithic structures. Specific issues related to the microchip electrochromatography, i.e. importance of high aspect ratio of the microchannels in the open-channel electrochromatography or approaches eliminating the wall effect in the monolithbased electrochromatography, are discussed. Various applications for environmental, pharmacological, genomic and proteomic analysis are described. The operation parameters of reviewed microsystems are summarized in easy-to-read tables. (c) 2005 Elsevier B.V. All rights reserved.

引用

页码：1048 / 1062

页数：15

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