Inhibition of virus replication by RNA interference

被引：124

作者：

Haasnoot, J ^{[1
]}

Cupac, D ^{[1
]}

Berkhout, B ^{[1
]}

机构：

[1] Univ Amsterdam, Acad Med Ctr K3110, Dept Human Retrovirol, NL-1105 AZ Amsterdam, Netherlands

来源：

JOURNAL OF BIOMEDICAL SCIENCE | 2003年 / 10卷 / 06期

关键词：

RNA interference; siRNA; virus; replication;

D O I：

10.1007/BF02256311

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

RNA interference (RNAi) is a sequence-specific gene-silencing mechanism in eukaryotes, which is believed to function as a defence against viruses and transposons. Since its discovery, RNAi has been developed into a widely used technique for generating genetic knock-outs and for studying gene function by reverse genetics. Additionally, inhibition of virus replication by means of induced RNAi has now been reported for numerous viruses, including several important human pathogens such as human immunodeficiency virus type 1, hepatitis C virus, hepatitis B virus, dengue virus, poliovirus and influenza virus A. In this review, we will summarize the current data on RNAi-mediated inhibition of virus replication and discuss the possibilities for the development of RNAi-based antiviral therapeutics. Copyright (C) 2003 National Science Council, ROC and S. Karger AG, Basel.

引用

页码：607 / 616

页数：10

共 72 条

[1] RNA silencing of dengue virus type 2 replication in transformed C6/36 mosquito cells transcribing an inverted-repeat RNA derived from the virus genome [J].

Adelman, ZN ;

Sanchez-Vargas, I ;

Travanty, EA ;

Carlson, JO ;

Beaty, BJ ;

Blair, CD ;

Olson, KE .

JOURNAL OF VIROLOGY, 2002, 76 (24) :12925-12933

[2] Sindbis virus-induced silencing of dengue viruses in mosquitoes [J].

Adelman, ZN ;

Blair, CD ;

Carlson, JO ;

Beaty, BJ ;

Olson, KE .

INSECT MOLECULAR BIOLOGY, 2001, 10 (03) :265-273

[3] Retroviral delivery of small interfering RNA into primary cells [J].

Barton, GM ;

Medzhitov, R .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (23) :14943-14945

[4] Viral suppression of systemic silencing [J].

Baulcombe, D .

TRENDS IN MICROBIOLOGY, 2002, 10 (07) :306-308

[5] Hepatitis viruses: Their role in human cancer [J].

Bradley, DW .

PROCEEDINGS OF THE ASSOCIATION OF AMERICAN PHYSICIANS, 1999, 111 (06) :588-593

[6] RETRACTED: Viral pathogenicity determinants are suppressors of transgene silencing in Nicotiana benthamiana (Retracted article. See vol. 34, pg. 2595, 2015) [J].

Brigneti, G ;

Voinnet, O ;

Li, WX ;

Ji, LH ;

Ding, SW ;

Baulcombe, DC .

EMBO JOURNAL, 1998, 17 (22) :6739-6746

[7] A system for stable expression of short interfering RNAs in mammalian cells [J].

Brummelkamp, TR ;

Bernards, R ;

Agami, R .

SCIENCE, 2002, 296 (5567) :550-553

[8]

BRUMMELKAMP TR, UNPUB HIV 1 ESCAPES

[9] Inhibition of viral gene expression and replication in mosquito cells by dsRNA-triggered RNA interference [J].

Caplen, NJ ;

Zheng, ZL ;

Falgout, B ;

Morgan, RA .

MOLECULAR THERAPY, 2002, 6 (02) :243-251

[10] Inhibition of HIV-1 infection by small interfering RNA-mediated RNA interference [J].

Capodici, J ;

Karikó, K ;

Weissman, D .

JOURNAL OF IMMUNOLOGY, 2002, 169 (09) :5196-5201

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