Viral suppression of systemic silencing

被引：71

作者：

Baulcombe, D ^{[1
]}

机构：

[1] John Innes Ctr, Sainsburg Lab, Norwich NR4 7UH, Norfolk, England

来源：

TRENDS IN MICROBIOLOGY | 2002年 / 10卷 / 07期

关键词：

D O I：

10.1016/S0966-842X(02)02387-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

RNA silencing in plants is a form of antiviral defense that was originally discovered from the anomalous effects of transgenes. The process is associated with a systemic signal, presumed to be RNA, and is suppressed by plant virus-encoded proteins. One of these proteins, the 2b protein of cucumber mosaic virus, prevents systemic spread of the signal molecule but, curiously, is located in the nucleus of infected cells. The antiviral role of silencing might also apply in animals because a suppressor of silencing encoded by an insect virus was identified recently.

引用

页码：306 / 308

页数：3

共 20 条

[1] RETRACTED: Viral pathogenicity determinants are suppressors of transgene silencing in Nicotiana benthamiana (Retracted article. See vol. 34, pg. 2595, 2015) [J].

Brigneti, G ;

Voinnet, O ;

Li, WX ;

Ji, LH ;

Ding, SW ;

Baulcombe, DC .

EMBO JOURNAL, 1998, 17 (22) :6739-6746

[2] Subcellular localization determines the availability of non-targeted proteins to plasmodesmatal transport [J].

Crawford, KM ;

Zambryski, PC .

CURRENT BIOLOGY, 2000, 10 (17) :1032-1040

[3] A NOVEL NATURALLY-OCCURRING HYBRID GENE ENCODED BY A PLANT RNA VIRUS FACILITATES LONG-DISTANCE VIRUS MOVEMENT [J].

DING, SW ;

LI, WX ;

SYMONS, RH .

EMBO JOURNAL, 1995, 14 (23) :5762-5772

[4]

English JJ, 1996, PLANT CELL, V8, P179, DOI 10.1105/tpc.8.2.179

[5] Systemic silencing signal(s) [J].

Fagard, M ;

Vaucheret, H .

PLANT MOLECULAR BIOLOGY, 2000, 43 (2-3) :285-293

[6] Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans [J].

Fire, A ;

Xu, SQ ;

Montgomery, MK ;

Kostas, SA ;

Driver, SE ;

Mello, CC .

NATURE, 1998, 391 (6669) :806-811

[7]

Goodwin J, 1996, PLANT CELL, V8, P95, DOI 10.1105/tpc.8.1.95

[8] A viral protein inhibits the long range signaling activity of the gene silencing signal [J].

Guo, HS ;

Ding, SW .

EMBO JOURNAL, 2002, 21 (03) :398-407

[9] A species of small antisense RNA in posttranscriptional gene silencing in plants [J].

Hamilton, AJ ;

Baulcombe, DC .

SCIENCE, 1999, 286 (5441) :950-952

[10] Post-transcriptional gene silencing by double-stranded RNA [J].

Hammond, SM ;

Caudy, AA ;

Hannon, GJ .

NATURE REVIEWS GENETICS, 2001, 2 (02) :110-119

← 1 2 →