Anti-inflammatory activity of lupeol and lupeol linoleate in rats

被引：175

作者：

Geetha, T ^{[1
]}

Varalakshmi, P ^{[1
]}

机构：

[1] Univ Madras, Dr AL Mudaliar Post Grad Inst Basic Med Sci, Dept Biochem Med, Madras 600113, Tamil Nadu, India

来源：

JOURNAL OF ETHNOPHARMACOLOGY | 2001年 / 76卷 / 01期

关键词：

anti-inflammatory; antinociceptive; anti-pyretic; lupeol; lupeol linoleate; ulcerogenic;

D O I：

10.1016/S0378-8741(01)00175-1

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Two pentacyclic triterpenes. namely lupeol and lupeol linoleate, were investigated for their anti-inflammatory, antinociceptive. anti-pyretic and ulcerogenic properties in comparison with the commonly used non-steroidal anti-inflammatory drug, indomethacin in rats. Lupeol, lupeol linoleate and indomethacin showed a reduction in paw swelling by 39, 58 and 35%, respectively, in adjuvant arthritis. Triterpenes were devoid of any antinociceptive, anti-pyretic and ulcerogenic actions. However. indomethacin exhibited a positive response to these properties. These results suggest that the mechanism of action of triterpenes is different from the non-steroidal anti-inflammatory drug. (C) 2001 Published by Elsevier Science Ireland Ltd.

引用

页码：77 / 80

页数：4

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