Arming the enemy: the evolution of resistance to self-proteins

被引：110

作者：

Bell, G

Gouyon, PH

机构：

[1] McGill Univ, Dept Biol, Montreal, PQ H3A 1B1, Canada

[2] Univ Paris 11, Lab Ecol Syst & Evolut, F-91405 Orsay, France

来源：

MICROBIOLOGY-SGM | 2003年 / 149卷

关键词：

D O I：

10.1099/mic.0.26265-0

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

A remarkable range of novel antibiotics is attracting increasing interest as a major new weapon in the campaign against bacterial infection. They are based on the toxic peptides that provide the innate immune system of animals, and it is claimed that bacteria will be unable to evolve resistance to them because they attack the 'Achilles' heel' of bacterial membrane structure. Both experimental evidence and theoretical arguments suggest that this claim is doubtful. If so, the introduction of these substances into general use may provoke the evolution of resistance to our own defence proteins and thus compromise our natural defences against infection.

引用

收藏

页码：1367 / 1375

页数：9

相关论文

共 36 条

[1] The biological cost of antibiotic resistance [J].

Andersson, DI ;

Levin, BR .

CURRENT OPINION IN MICROBIOLOGY, 1999, 2 (05) :489-493

[2]

Andreu D, 1998, BIOPOLYMERS, V47, P415, DOI 10.1002/(SICI)1097-0282(1998)47:6<415::AID-BIP2>3.0.CO

[3]

2-D

[4] The relationship between the volume of antimicrobial consumption in human communities and the frequency of resistance [J].

Austin, DJ ;

Kristinsson, KG ;

Anderson, RM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (03) :1152-1156

[5] In vitro resistance to thrombin-induced platelet microbicidal protein among clinical bacteremic isolates of Staphylococcus aureus correlates with an endovascular infectious source [J].

Bayer, AS ;

Cheng, D ;

Yeaman, MR ;

Corey, GR ;

McClelland, RS ;

Harrel, LJ ;

Fowler, VG .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1998, 42 (12) :3169-3172

[6] In vitro resistance of Staphylococcus aureus to thrombin-induced platelet microbicidal protein is associated with alterations in cytoplasmic membrane fluidity [J].

Bayer, AS ;

Prasad, R ;

Chandra, J ;

Koul, A ;

Smriti, M ;

Varma, A ;

Skurray, RA ;

Firth, N ;

Brown, MH ;

Koo, SP ;

Yeaman, MR .

INFECTION AND IMMUNITY, 2000, 68 (06) :3548-3553

[7]

Crandall AD, 1998, APPL ENVIRON MICROB, V64, P231

[8] RESISTANCE TO HOST ANTIMICROBIAL PEPTIDES IS NECESSARY FOR SALMONELLA VIRULENCE [J].

GROISMAN, EA ;

PARRALOPEZ, C ;

SALCEDO, M ;

LIPPS, CJ ;

HEFFRON, F .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (24) :11939-11943

[9] A PhoP-regulated outer membrane protease of Salmonella enterica serovar typhimurium promotes resistance to alpha-helical antimicrobial peptides [J].

Guina, T ;

Yi, EC ;

Wang, HL ;

Hackett, M ;

Miller, SI .

JOURNAL OF BACTERIOLOGY, 2000, 182 (14) :4077-4086

[10] Peptide antibiotics [J].

Hancock, REW ;

Chapple, DS .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1999, 43 (06) :1317-1323

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