The pleiotropic functions of the Y-box-binding protein, YB-1

被引：435

作者：

Kohno, K ^{[1
]}

Izumi, H

Uchiumi, T

Ashizuka, M

Kuwano, M

机构：

[1] Univ Occupat & Environm Hlth, Sch Med, Dept Mol Biol, Kitakyushu, Fukuoka 8078555, Japan

[2] Kyushu Univ, Grad Sch Med Sci, Dept Med Biochem, Fukuoka 812, Japan

[3] Kurume Univ, Res Ctr Innovat Canc Therapy, Kurume, Fukuoka 830, Japan

来源：

BIOESSAYS | 2003年 / 25卷 / 07期

关键词：

D O I：

10.1002/bies.10300

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The Y-box-binding protein (YB-1) represents the most evolutionary conserved nucleic-acid-binding protein currently known. YB-1 is a member of the cold-shock domain (CSD) protein superfamily. It performs a wide variety of cellular functions, including transcriptional regulation, translational regulation, DNA repair, drug resistance and stress responses to extracellular signals. As a result, YB-1 expression is closely associated with cell proliferation. In this review, we will begin by briefly describing the characteristics of YB-1 and will then summarize the pleiotropic functions brought about via DNA-RNA transaction and protein-protein interactions. In addition, we will discuss the diverse range of potential physiological and pathological functions of YB-1. (C) 2003 Wiley Periodicals, Inc.

引用

页码：691 / 698

页数：8

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