Recent studies demonstrate that the factors involved in mRNA processing specify the fate of a transcript. The mRNA is either committed for export to the cytoplasm or accumulates in the nucleus, where it may be degraded. These studies reveal crosstalk among the nuclear events faced by the pre-mRNA. It is becoming evident that the components of the mRNA synthesis machinery interact with each other to establish a distinct surveillance mechanism that determines release of the transcript from the transcription site for further export and utilisation. Recent advances suggest that the major nuclear decay machinery, the nuclear exosome, and an Rrp6p-specific complex coordinate with processing factors to perform a unique regulatory function that determines its fate: either confinement of the defective mRNA at its transcription site, or release from its site of transcription for further processing and export or decay. Furthermore, message-specific regulatory mechanisms correspond with the nuclear mRNA synthesis machinery to control gene expression.
机构:Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Dept Mol Genet & Microbiol, Piscataway, NJ 08854 USA
Wilusz, CJ
;
Wormington, M
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机构:Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Dept Mol Genet & Microbiol, Piscataway, NJ 08854 USA
Wormington, M
;
Peltz, SW
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机构:
Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Dept Mol Genet & Microbiol, Piscataway, NJ 08854 USAUniv Med & Dent New Jersey, Robert Wood Johnson Med Sch, Dept Mol Genet & Microbiol, Piscataway, NJ 08854 USA
机构:
NCI, Frederick Canc Res & Dev Ctr, Basic Res Lab, Human Retrovirus Pathogenesis Sect,Ctr Canc Res, Frederick, MD 21702 USANCI, Frederick Canc Res & Dev Ctr, Basic Res Lab, Human Retrovirus Pathogenesis Sect,Ctr Canc Res, Frederick, MD 21702 USA
Zolotukhin, AS
;
Michalowski, D
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NCI, Frederick Canc Res & Dev Ctr, Basic Res Lab, Human Retrovirus Pathogenesis Sect,Ctr Canc Res, Frederick, MD 21702 USANCI, Frederick Canc Res & Dev Ctr, Basic Res Lab, Human Retrovirus Pathogenesis Sect,Ctr Canc Res, Frederick, MD 21702 USA
Michalowski, D
;
Smulevitch, S
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机构:
NCI, Frederick Canc Res & Dev Ctr, Basic Res Lab, Human Retrovirus Pathogenesis Sect,Ctr Canc Res, Frederick, MD 21702 USANCI, Frederick Canc Res & Dev Ctr, Basic Res Lab, Human Retrovirus Pathogenesis Sect,Ctr Canc Res, Frederick, MD 21702 USA
Smulevitch, S
;
Felber, BK
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机构:
NCI, Frederick Canc Res & Dev Ctr, Basic Res Lab, Human Retrovirus Pathogenesis Sect,Ctr Canc Res, Frederick, MD 21702 USANCI, Frederick Canc Res & Dev Ctr, Basic Res Lab, Human Retrovirus Pathogenesis Sect,Ctr Canc Res, Frederick, MD 21702 USA
机构:Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Dept Mol Genet & Microbiol, Piscataway, NJ 08854 USA
Wilusz, CJ
;
Wormington, M
论文数: 0引用数: 0
h-index: 0
机构:Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Dept Mol Genet & Microbiol, Piscataway, NJ 08854 USA
Wormington, M
;
Peltz, SW
论文数: 0引用数: 0
h-index: 0
机构:
Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Dept Mol Genet & Microbiol, Piscataway, NJ 08854 USAUniv Med & Dent New Jersey, Robert Wood Johnson Med Sch, Dept Mol Genet & Microbiol, Piscataway, NJ 08854 USA
机构:
NCI, Frederick Canc Res & Dev Ctr, Basic Res Lab, Human Retrovirus Pathogenesis Sect,Ctr Canc Res, Frederick, MD 21702 USANCI, Frederick Canc Res & Dev Ctr, Basic Res Lab, Human Retrovirus Pathogenesis Sect,Ctr Canc Res, Frederick, MD 21702 USA
Zolotukhin, AS
;
Michalowski, D
论文数: 0引用数: 0
h-index: 0
机构:
NCI, Frederick Canc Res & Dev Ctr, Basic Res Lab, Human Retrovirus Pathogenesis Sect,Ctr Canc Res, Frederick, MD 21702 USANCI, Frederick Canc Res & Dev Ctr, Basic Res Lab, Human Retrovirus Pathogenesis Sect,Ctr Canc Res, Frederick, MD 21702 USA
Michalowski, D
;
Smulevitch, S
论文数: 0引用数: 0
h-index: 0
机构:
NCI, Frederick Canc Res & Dev Ctr, Basic Res Lab, Human Retrovirus Pathogenesis Sect,Ctr Canc Res, Frederick, MD 21702 USANCI, Frederick Canc Res & Dev Ctr, Basic Res Lab, Human Retrovirus Pathogenesis Sect,Ctr Canc Res, Frederick, MD 21702 USA
Smulevitch, S
;
Felber, BK
论文数: 0引用数: 0
h-index: 0
机构:
NCI, Frederick Canc Res & Dev Ctr, Basic Res Lab, Human Retrovirus Pathogenesis Sect,Ctr Canc Res, Frederick, MD 21702 USANCI, Frederick Canc Res & Dev Ctr, Basic Res Lab, Human Retrovirus Pathogenesis Sect,Ctr Canc Res, Frederick, MD 21702 USA